Data Mining and Meta-Analysis
A need for data-mining arose during the investigation of interplay between two classes of proteins in a whole-genome scope - namely of GTPases activation by GEF proteins. It was necessary to compare experimental data with information about the sequences and structures of all related proteins. Extracted and processed data have been put into a form of interaction matrix. It enables to identify crucial features for interaction between proteins and is applicable to any pairs of interacting proteins with homologous structural fold.